Figure 7.

SARM is downregulated in NK/T-cell lymphoma patient tissues. RNA was extracted either from formalin-fixed paraffin-embedded patient extranodal tissues (n=6) or healthy NK cells (n=2) or IL-2 stimulated healthy NK cells (n=2) or NK/T-cell lymphoma cell lines (n=6). cDNA, reverse-transcribed from RNA was used as template for real-time PCR and data were normalized to human glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Relative quantification (RQ) of SARM expression (a) between healthy NK cells, stimulated NK cells and NK/T-cell lymphoma tissue, and (b) between healthy NK cells and NK/T-cell lymphoma-derived cell lines. Each sample is represented by a triangle. Black line indicates the mean of each group. *P<0.005; **P<0.0005