Figure 2.

Representative immunohistochemical analysis of superficial human TCC of bladder expressing high levels of NQO1 (A), the glucose transporter GLUT1 (B) and pimonidazole-treated tumour (C). GLUT1 and pimonidazole have been used as endogenous and exogenous markers of hypoxia respectively (Rademakers et al., 2011). The brown staining in panels A to C represents areas of positive staining. Appearance of marker lesion (ML) in situ before (D) and after (E) a 6 week course of EO9 administered intravesically once a week at a dose of 4 mg/40 mL.