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SIRT6 expression was increased and deacetylase activity were decreased in AAC rats. Rats were sampled at different times (2–8 weeks, as shown) after induction of AAC. The mRNA expression (A), protein expression (B), deacetylase activity (C) of SIRT6 and NAD content (D) were measured. Data are presented as means ± SE. *P < 0.05, significantly different from sham group, n= 6.
