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VIP-mediated relaxation is diminished in HO2-/- mice. NANC relaxation in WT, HO2-/-, and nNOS-/- mice in response to exogenous VIP was examined, as shown in Fig. 2. VIP-induced relaxation is reduced significantly in HO2-/- mice and augmented in nNOS-/- mice. Results are expressed as a percentage of SNP-induced relaxation. Data are expressed as mean ± SEM of five separate experiments. *, P < 0.02, compared with WT.
