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. 2012 Dec 18;168(1):189–199. doi: 10.1111/j.1476-5381.2012.02123.x

Figure 2.

Figure 2

Effect of rHuEPO and modified EPOs on in vivo erythropoiesis. rHuEPO and modified EPOs at the doses of 0.3 mg kg−1 were s.c. injected in mice (n = 5 each) at days 0, 3, 7, 10 and 12 (about 6000-fold the starting dosage for the treatment of renal anaemia in humans). The results showed that GEPO was completely devoid of erythropoietic activities. Substantial activity loss was also observed with CEPO and SEPO.