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Activation of Bcl-2 by rHuEPO and non-erythropoietic derivatives. Representative immunoblot of Bcl-2 from three independent experiments, indicating that Bcl-2 was markedly lower in unstimulated P19 cells. rHuEPO and GEPO treatments markedly increased Bcl-2 levels. In addition, Bcl-2 activation by rHuEPO and GEPO was inhibited by a JAK-2 inhibitor. In contrast, activation of Bcl-2 by CEPO was less impressive and independent of JAK-2 inhibition.
