Figure 1.

Antibody affinity goal predictions using in silico translational simulations. The biomathematical model assumed 50% s.c. absolute bioavailability, 2.5 mL kg⁻¹ day⁻¹ IgG clearance by the reticuloendothelial system, a distribution volume of 64 mL kg⁻¹ and 20 pM GM-CSFRα with a 1 h internalization rate for the receptor and antibody–receptor complex. Simulations were performed to predict the unoccupied receptor level in humans following a single 1 mg kg⁻¹ s.c. dose.