Table 2.

Effect of Ac-ANX-A1_2–26 (added to the perfusion buffer after one hour of drug-free perfusion) on LV function in the normoxic adult rat heart ex vivo

		Min post addition of Ac-ANX-A12–26
Parameter	Treatment	0	1	2	5	10	20	30	AUC	n
LVDP (% baseline, P = NS)	sham	99 ± 5	98 ± 5	95 ± 6	95 ± 6	93 ± 7	96 ± 7	92 ± 8	2850 ± 190	9
	Ac-ANX-A12–26	121 ± 8	111 ± 14	111 ± 14	121 ± 15	124 ± 15	128 ± 12	127 ± 14	3720 ± 404	4
LVRPP (% baseline, P = NS)	sham	93 ± 7	110 ± 15	107 ± 12	113 ± 20	117 ± 29	118 ± 22	102 ± 9	3340 ± 443	6
	Ac-ANX-A12–26	127 ± 9	116 ± 13	117 ± 15	130 ± 15	134 ± 16	136 ± 12	131 ± 9	3950 ± 441	4
LV + dP/dt (% baseline, P < 0.05)	sham	99 ± 4	96 ± 4	96 ± 4	91 ± 4	94 ± 5	96 ± 6	99 ± 6	2860 ± 167	8
	Ac-ANX-A12–26	117 ± 7	113 ± 11	111 ± 11	119 ± 12	123 ± 12	125 ± 10	121 ± 11	3650 ± 312	4
LV-dP/dt (% baseline, P < 0.005)	sham	94 ± 5	93 ± 4	94 ± 4	89 ± 4	93 ± 4	95 ± 5	97 ± 6	2810 ± 119	8
	Ac-ANX-A12–26	117 ± 3	115 ± 10	113 ± 9	119 ± 9	122 ± 9	123 ± 4	117 ± 7	3600 ± 188	4
LDH (IU·L−1, P < 0.05)	sham	−6 ± 4	−6 ± 6	−5 ± 4	−4 ± 4	−3 ± 4	−5 ± 3	ND	130 ± 45	4
	Ac-ANX-A12–26	−19 ± 7	−33 ± 8	−32 ± 7	−39 ± 5	−44 ± 6	−13 ± 13	ND	670 ± 130	4