Table 4.
The extent of LV dysfunction following I–R injury was not affected by sex, in either hearts isolated from annexin-A1 wild-type or ANX-A1−/− mice ex vivo
| LVDP (% baseline, min post reperfusion) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental group | 0 | 1 | 2 | 5 | 10 | 20 | 30 | 40 | AUC x 103 | n |
| Wild-type male I–R | 51 ± 19 | 94 ± 27 | 57 ± 9 | 53 ± 9 | 50 ± 9 | 56 ± 11 | 63 ± 12 | 65 ± 13 | 2.33 ± 0.43 | 7 |
| Wild-type female I–R | 34 ± 9 | 75 ± 13 | 60 ± 7 | 45 ± 9 | 44 ± 13 | 60 ± 9 | 65 ± 8 | 63 ± 5 | 2.27 ± 0.31 | 4 |
| ANX-A1−/− male I–R | 27 ± 4 | 56 ± 85 | 37 ± 6 | 10 ± 35 | 13 ± 35 | 28 ± 6 | 29 ± 7 | 29 ± 75 | 1.00 ± 0.205 | 8 |
| ANX-A1−/− female I–R | 17 ± 5 | 57 ± 9 | 33 ± 9 | 16 ± 5 | 21 ± 7 | 30 ± 6 | 33 ± 5 | 34 ± 5 | 1.13 ± 0.20 | 6 |
Analysis of the time course of recovery of LVDP over 40 min of reperfusion on two-way anova indicates that P(min post reperfusion) < 0.0001; P(experimental group) < 0.0001; P(interaction) = NS. Analysis of AUC for LVDP on two-way anova indicates that P(gender) = NS; P(experimental group) < 0.001; P(interaction) = NS.
On two-way anova with SNK post hoc analysis, hearts from male ANX-A1−/− have poorer recovery from I–R injury than male wild-type mice (P < 0.01). No significant differences were observed between male and female mice of either genotype.