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. 2013 Feb 11;210(2):287–300. doi: 10.1084/jem.20122149

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© 2013 Aichinger et al.

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Figure 6. — mTECs directly present GCL, but not GCL_G120A, for negative selection. (a) Thymocyte subsets in WT, Aire-GCL, or Aire-GCL_G120A recipients 4–5 wk after reconstitution with DEP BM cells. Dot plots show the mean frequency ± SD of CD4SP cells (top row) and of DEP-TCR⁺ cells (Vα11⁺Vβ5.1⁺) among gated CD4SP cells (bottom row). Data are representative of ≥10 chimeras per group. (b) WT, Aire-GCL, or Aire-GCL_G120A recipients were reconstituted with DEP × ΔDC BM. 4–5 wk later, thymi were analyzed by flow cytometry. Plots show the mean frequency ± SD of CD4SP cells (top row) and of DEP-TCR⁺ cells (Vα11⁺Vβ5.1⁺) among gated CD4SP cells (bottom row). Data are representative of nine or more chimeras per group. (c) Frequencies of CD4SP Vα11⁺Vβ5.1⁺ cells among total thymocytes in a and b.