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. 2013 Feb 11;210(2):287–300. doi: 10.1084/jem.20122149

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© 2013 Aichinger et al.

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Figure 8. — Indirect presentation by DCs can compensate for impaired direct presentation by mTECs in Aire-GCL thymi. (a) Subsets in Atg5^+/− or Atg5^−/− thymi 4–6 wk after transplantation into DEP × MHC Class II^+/+ recipients. Plots show the mean frequency ± SD of CD4SP cells (top row) and of DEP-TCR⁺ cells (Vα11⁺Vβ5.1⁺) among gated CD4SP thymocytes (bottom row). Data are representative of ≥19 chimeras per group. (b) Thymocyte subsets in Aire-GCL × Atg5^+/− or Aire-GCL × Atg5^−/− thymic lobes 4 to 6 wk after transplantation into DEP × MHC Class II^+/+ recipients. Plots show the mean frequency ± SD of CD4SP cells (top row) and of DEP-TCR⁺ cells (Vα11⁺Vβ5.1⁺) among gated CD4SP thymocytes (bottom row). Data are representative of ≥10 chimeras per group. (c) Frequencies and absolute numbers of CD4SP Vα11⁺Vβ5.1⁺ cells in a and b.