CP modulated the production of cytokines and chemokines in optic nerve in EAE rats. (A) Cytokines and chemokines in in optic nerve of EAE rats, determined using an ELISpot Cytokine Array kit. Bar diagrams for levels of the pro-iflammatory cytokines (A): IL-1a/b, IL-2, IL-ra, IL-3, IFN-γ, and TNF-a; anti-iflammatory cytokines (B): IL-4, IL-6, and IL-10; and chemokines (D): CXCL-10, CXCL-9, CCL-3, CCL-9 expression (n ≥ 3 per group, *p ≤ 0.05 compared with untreated control (Con); #p ≤ 0.05 compared with EAE-CP0).