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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Neurochem. 2012 Nov 22;124(1):133–146. doi: 10.1111/jnc.12064

Figure 5.

Figure 5

Calpain inhibition decreased apoptosis in optic nerve in EAE Rats. Representative (A) Western blots and corresponding (B) Bax:Bcl-2 ratio; (C) bar diagrams (densitometry) showing levels of expression of 24 and 21 kD Bax, 26 kD Bcl-2, 18 kD caspase-8, 15 kD tBid, 120 kD SBDP, 12 kD caspase-3, and 87 kD PARP-1 in optic nerve of EAE rats (n ≥ 3 per group, *p ≤ 0.05 compared with untreated control (Con); #p ≤ 0.05 compared with EAE-CP0). (D) Agarose gel electrophoresis of genomic DNA samples for detection of internucleosomal DNA fragmentation.