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. Author manuscript; available in PMC: 2013 Feb 12.
Published in final edited form as: Oncogene. 2011 Sep 5;31(15):1938–1948. doi: 10.1038/onc.2011.377

Figure 3.

Figure 3

Survivin-targeting molecule S12 causes mitotic arrest. (a) HeLa cells were treated with S12 (20 µm), control compound S1 or DMSO (control) for 15 h. Cells were examined by propidium iodide staining of DNA content and by fluorescence-activated cell sorting analysis. Note that the cells treated by S12 demonstrated an increase in G2/M population. (b) Immunofluorescence analysis of cells treated with S12. HeLa cells were treated with either DMSO or S12 (40 µm) for 18 h. Cells were immunostained with anti-aurora B antibody (green) and anti-survivin antibody (red). (c) Percentage of S12-treated cells in mitosis, in metaphase, in anaphase/telophase or with misaligned chromosomes. The error bars represent s.d.