Figure 4.

Effects of PAG and L-cys on CSE expression in gastric mucosa from rats subjected to gastric ischemia-reperfusion (GI-R). Male Sprague-Dawley rats were intraperitoneally injected with the H₂S synthetase blocker PAG (50 mg/kg) or L-cys (50 mg/kg) for 7 days before the celiac arteries were clamped for 30 min ischemia and then reperfused for 60 min. Sham group, age-matched rats with physiological solute treatment but no GI-R procedure; GI-R group, age-matched rats with physiological solute treatment followed by the GI-R procedure; PAG group, rats intraperitoneally injected with PAG and then subjected to the GI-R procedure; L-cys group, rats intraperitoneally injected with L-cys and then subjected to the GI-R procedure. Data presented as mean ± standard deviation (SD), n=3. ^**P<0.01 vs. the sham group, ^##P<0.01 vs. the GI-R group, ^ΔΔP<0.01 vs. the PAG group. PAG, DL-propargylglycine; L-cys, L-cysteine; H₂S, hydrogen sulfide; CSE, cystathionine γ-lyase.