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MSC paracrine signaling increases SERCA mediated Ca uptake. Representative F/F0 plots from field stimulated VMs incubated in (A) Ctrl and (B) ConT where the SR was depleted by application of caffeine (10 mM). (C) Summary data of caffeine transient amplitude in Ctrl (black) and ConT (white) treated cells. Summary data of the time constant of caffeine transient decay (τcaf) in the presence of (E) caffeine and (D) 0 Ca + Nickel. (*=p<0.05).
