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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2012 Mar 23;52(6):1249–1256. doi: 10.1016/j.yjmcc.2012.03.008

Fig. 6.

Fig. 6

Changes in EC coupling are induced by ConT mediated activation of PI3K and Akt. (A) Change in Ca transient amplitude and τCa (B) as % of Ctrl after 15 min superfusion with ConTm, ConTh (white), insulin (light gray), or ConT in the presence of the PI3K inhibitors wortmannin [WM: 100 nmol/L] (gray) or LY294002 [LY: 10 μmol/L] (black). (C) Western blotting shows that LY, WM and Akt iV [25 μM] suppress ConT (30 min) mediated phosphorylation of Akt. Total Akt (pan-Akt) is shown as a loading control. (D) ConT (●) induced changes in [Ca]i or (E) τCa are suppressed by pretreatment with the Akt inhibitor V [20 μmol/L] (■).

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