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Changes in EC coupling depend on the activation of eNOS. Changes in Ca transient amplitude (A) and τCa (B) upon superfusion with ConT (o), ConT plus nNOS inhibitor SMLT (10 μmol/L; gray ◊), or eNOS inhibitor L-NIO (1 μmol/L; ▲). Summary of the experimental results for Ca transient amplitude (C) or τCa (D) after 15 min of superfusion (*=p<0.05). (E) Pictoral summarizing the signal transduction pathway proposed based on the experimental results.
