Figure 1.

Vessel dilator (VDL), kaliuretic peptide (KP), atrial natriuretic peptide (ANP) and long-acting natriuretic peptide (LANP) maximally reduced the level of secreted frizzled-related protein 3 (sFRP-3) (in pg/ml) in human colorectal cancer cells by 83%, 83%, 84% and 83%, respectively. Each of these reductions was significant at P<0.0001 when evaluated by the Student’s t-test for unpaired values. Each bar represents the mean ± SEM of 32 determinations for the control and 6 determinations for the experimental groups.