Table 1.
Effect of spaceflight on M-CSF differentiated bone marrow-derived cell phenotypic markers.
| Cell marker | Subpopulation | Spaceflight | Ground control |
|---|---|---|---|
| Ly6C* | Total cells | 5.8a | 9.2 |
| R1 | 20.0 | 24.7 | |
| R2 | 2.9 | 4.5 | |
| R3 | 0.5 | 7.1 | |
| R4 | 1.1 | 4.7 | |
| c-Fms | Total cells | 34.8 | 30.3 |
| R1 | 77.4 | 67.9 | |
| R2 | 56.2 | 37.4 | |
| R3 | 45.0 | 35.3 | |
| R4 | 10.5 | 9.4 | |
| CD11b* | Total cells | 0.1 | 6.7 |
| R1 | 1.2 | 1.4 | |
| R2 | 0 | 7.8 | |
| R3 | 0 | 57.3 | |
| R4 | 0 | 49.9 | |
| CD44 | Total cells | 45.4 | 45.7 |
| R1 | 62.7 | 67.0 | |
| R2 | 23.9 | 31.8 | |
| R3 | 16.3 | 16.8 | |
| R4 | 6.0 | 3.4 | |
| CD31 (PECAM) * | Total cells | 4.8 | 3.2 |
| R1 | 3.8 | 2.8 | |
| R2 | 14.2 | 4.1 | |
| R3 | 19.0 | 4.5 | |
| R4 | 13.3 | 15.1 | |
| Ly6G (Gr-1) | Total cells | 32.6 | 30.0 |
| R1 | 39.7 | 41.0 | |
| R2 | 11.5 | 8.4 | |
| R3 | 6.6 | 8.9 | |
| R4 | 4.3 | 8.4 | |
| CD3 | Total cells | 0.4 | 0 |
| R1 | 0.1 | 0 | |
| R2 | 2.2 | 0 | |
| R3 | 0.8 | 0 | |
| R4 | 1.5 | 0 | |
| F4/80* | Total cells | 5.0 | 2.7 |
| R1 | 11.6 | 3.7 | |
| R2 | 10.4 | 5.2 | |
| R3 | 1.4 | 0.1 | |
| R4 | 1.0 | 0.0 | |
| Mac2 * | Total cells | 5.5 | 4.5 |
| R1 | 8.5 | 0.5 | |
| R2 | 8.6 | 0 | |
| R3 | 6.2 | 0.4 | |
| R4 | 4.7 | 0.6 | |
| c-Fos * | Total cells | 2.5 | 3.3 |
| R1 | 3.7 | 4.0 | |
| R2 | 8.0 | 3.6 | |
| R3 | 10.6 | 0 | |
| R4 | 7.7 | 0 |
Numbers indicate % of cells above isotype control staining; 20,000 cells analyzed per sample. R1, region 1; R2, region 2; R3, region 3; R4, region 4.
*
Indicates flight sample is distributed differently from ground control as assessed by χ2 analysis.