Table 4.

M-CSF pathway of bone marrow derived macrophages gene regulation due to spaceflight.

Gene symbol	Entrez gene ID	Gene name	p-Valuea	Fold change
Csf1r	12978	Colony stimulating factor 1 receptor	0.04*	−1.6
Hras1	15461	Harvey rat sarcoma virus oncogene 1	0.24	−1.3
Ets1	23871	E26 avian leukemia oncogene 1,5′ domain	0.59	1.3
Ets2	23872	E26 avian leukemia oncogene 2,3′ domain	0.79	1.1
Etv3	27049	ETS-domain transcriptional repressor, METS, Pe1	0.32	−2.0
Ddx20	53975	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20, Dp103.	0.83	−1.1
Jun	16476	Jun oncogene	0.62	1.3
Fos	14281	FBJ osteosarcoma oncogene	0.14	−1.9
Sin3	20467	Transcriptional regulator, SIN3B (yeast)	0.89	−1.0
Hdac2	15182	Histone deacetylase 2	0.92	1.0
Ncord2	20602	Nuclear receptor co-repressor 2	0.37	−1.2
E2f4	104394	E2F transcription factor 4	0.04*	−1.6
Rbl-1	19650	Retinoblastoma-like 1 (p107)	0.02*	-4.4
Rbl-2	19651	Retinoblastoma-like 2	0.35	−1.4
Hoxb7	15415	Homeobox B7	0.08	1.1
Egr1	13653	Early growth response 1	0.03	2.1
Irf1	16362	Interferon regulatory factor 1	0.79	−1.0
Chrac1	93696	Chromatin accessibility complex 1	0.50	−1.1
Hoxb4	15412	Homeobox B4	0.01	1.7
Hoxb3	15410	homeobox B3	0.03	1.2
Cebpa	12606	CCAAT/enhancer binding protein (C/EBP), alpha	0.10	−1.0
Cebpb	12608	CCAAT/enhancer binding protein (C/EBP), beta	0.09	1.1
Cebpg	12611	CCAAT/enhancer binding protein (C/EBP), gamma	0.69	−1.1
Gata1	14460	GATA binding protein 1	0.37	−1.5
Gata2	14461	GATA binding protein 2	0.04*	−2.1
Scly	50880	Selenocysteine lyase	0.38	1.1
Myb	17863	Myeloblastosis oncogene	0.19	1.8
Myc	17869	Myelocytomatosis oncogene	0.05	−1.7
Runx1	12394	Runt re1ated transcription factor 1	0.04*	−1.6
Tnf	21926	Tumor necrosis factor	0.66	−1.1
Stat3	20848	signal transducer and activator of transcription 3	0.64	−1.1
Sfpi1	20375	SFFV proviral integration 1	0.56	1.1
Zbtb16	235320	Zinc finger and BTB domain containing 16	0.21	1.2

^aGene expression data and IPA analysis was subjected to FDR (Benjamini–Holchberg) correction with a cut-off value at 0.05.

^*Indicates genes below the cut off.