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Organization and expression of the NR3C1 gene. The gene coding for the glucocorticoid receptor (GCR) is made up of nine exons. Exon 1 has seven basic transcriptional variants (Ex1A, Ex1D, Ex1E, Ex1B, Ex1F, Ex1C and Ex1H). The core exons of the gene are those from Ex2 to Ex8. Exon 9 determines two alternative splicing variants: isoform α and isoform β of the GCR. Detailed description and relevant literature in the text. Authors’ own elaboration based on (8,15,16).
