Table V.

Comparative analysis of NR3C1 gene Tth111I polymorphism frequency in healthy controls vs. patients with severe asthma characterized by a control profile corresponding to an ACT™ score ≥20.

	Healthy controls n (expected)	Severe asthma ACT™ score ≥20 n (expected)	OR	CI	Chi2	P-value
GG	64 (81.04)	8 (5.76)
AG	136 (101.92)	6 (10.48)
AA	15 (32.04)	7 (4.76)
[AG] vs. [GG]			0.095	0.028–0.318	19.87	8.23e-06
[AA] vs. [GG]			0.268	0.084–0.854	5.39	0.02028
[AA] vs. [AG+GG]			0.150	0.053–0.428	15.72	0.00007

The tests for association are adapted from Sasieni (42,43). OR, odds ratio; CI, confidence interval; ACT™, Asthma Control Test.