. Author manuscript; available in PMC: 2014 Jan 7.

Published in final edited form as: Mol Pharm. 2012 Dec 17;10(1):360–377. doi: 10.1021/mp300496x

Table 2.

Molecular characteristics of SODI-POx conjugates.

Conjugates^a	Linker	Modification degree^b	Residual activity (% unmodified)^c	T_m (°C)^d,e
SOD1-(cc)-P(MeOx-b-BuOx)	DSS	2.2	36	88.65
SOD1-(ss)-P(MeOx-b-BuOx)	DSP	3.5	47	N/A
SOD1-(cc)-P(EtOx-b-BuOx)	DSS	2.5	34	88.38
SOD1-(ss)-P(EtOx-b-BuOx)	DSP	2.3	31	N/A

Here “-(cc)-” and “-(ss)-” designate SOD1-POx conjugates containing stable and degradable bonds formed by DSS and DSP, respectively.

Counting per SOD1 dimer as determined by TNBS assay.

Determined by pyrogallol auto-oxidation assay.

Determined by DSC.

T_m of unmodified SOD1 is 92.14 °C.