Figure 4.

Treatment effects of different interventions relative to DTIC as obtained with random effects Weibull network meta-analysis expressed as hazard ratio (and 95% credible interval).A) Results without adjustment for differences in study date; B) Results after adjustment for differences in study date assuming treatment specific covariate interactions. Hazard ratios are presented corresponding to the average covariate value; C) Results after adjustment for differences in study date assuming constant covariate interaction. Hazard ratios are presented corresponding to the average covariate value