Table 1.
Associations of clinical and dose-volumetric parameters parameters with the rectosigmoid mucosal change score (RMC) ≥ 3 and late rectal complication (LRC) grade ≥ 2
| |
|
Total |
RMC |
|
LRC |
|
||
|---|---|---|---|---|---|---|---|---|
| Patients, n (%) | Score < 3, n (%) | ≥ Score 3, n (%) | p-value | Grade < 2, n (%) | Grade ≥ 3, n (%) | p-value | ||
| Age (years) |
≤ 60 |
50 (64.9) |
35 (70) |
15 (30) |
0.222* |
38 (76) |
12 (24) |
0.292* |
| |
> 60 |
27 (35.1) |
15 (55.6) |
12 (44.4) |
|
17 (63) |
10 (37) |
|
| Histology |
Squamous cell carcinoma |
70 (90.9) |
44 (62.9) |
26 (37.1) |
0.411* |
49 (70) |
21 (30) |
0.666* |
| |
Adenocarcinoma |
7 (9.1) |
6 (85.7) |
1 (14.3) |
|
6 (85.7) |
1 (14.3) |
|
| Tumor size (cm) |
≤ 4 |
41 (53.2) |
29 (70.7) |
12 (29.3) |
0.339* |
32 (78) |
9 (22) |
0.210* |
| |
> 4 |
36 (46.8) |
21 (58.3) |
15 (41.7) |
|
23 (63.9) |
13 (36.1) |
|
| Stage |
IB-IIA |
32 (41.6) |
27 (84.4) |
5 (15.6) |
0.003* |
29 (90.6) |
3 (9.4) |
0.002* |
| |
IIB-IIIB |
45 (58.4) |
23 (51.1) |
22 (48.9) |
|
26 (57.8) |
19 (42.2) |
|
| Concurrent chemotherapy |
Yes |
66 (85.7) |
43 (65.2) |
23 (34.8) |
1.000* |
48 (72.7) |
18 (27.3) |
0.719* |
| |
No |
11 (14.3) |
7 (63.6) |
4 (36.4) |
|
7 (63.6) |
4 (36.4) |
|
| Diabetes Mellitus |
Yes |
6 (7.8) |
5 (83.3) |
1 (16.7) |
0.417* |
5 (83.3) |
1 (16.7) |
0.668* |
| |
No |
71 (92.2) |
45 (16.7) |
26 (44.4) |
|
50 (70.4) |
21 (29.6) |
|
| Hypertension |
Yes |
20 (26) |
10 (50) |
10 (50) |
0.172* |
12 (60) |
8 (40) |
0.251* |
| |
No |
57 (74) |
40 (70.2) |
17 (29.8) |
|
43 (75.4) |
14 (24.5) |
|
| Smoking |
Yes |
12 (15.6) |
10 (83.3) |
2 (16.7) |
0.491* |
9 (75) |
3 (25) |
0.524* |
| |
No |
65 (84.4) |
45 (69.2) |
20 (30.8) |
|
41 (63.1) |
24 (36.9) |
|
| DRP (Gy3) |
(μ ± σ) |
|
69.1 ± 12.3 |
75.4 ± 18.3 |
0.124† |
69.2 ± 11.9 |
76.7 ± 20.0 |
0.120† |
| D0.1cc (Gy3) |
(μ ± σ) |
|
87.2 ± 15.6 |
101.7 ± 26.7 |
0.014† |
87.9 ± 15.9 |
103.1 ± 28.4 |
0.026† |
| D1cc (Gy3) |
(μ ± σ) |
|
75.1 ± 10.9 |
85.2 ± 14.4 |
0.001† |
75.8 ± 11.1 |
85.6 ± 15.2 |
0.002† |
| D2cc (Gy3) |
(μ ± σ) |
|
70.8 ± 9.8 |
79.6 ± 11.5 |
0.001† |
71.5 ± 9.9 |
79.9 ± 12.0 |
0.002† |
| D5cc (Gy3) |
(μ ± σ) |
|
64.6 ± 8.2 |
72.0 ± 8.4 |
< 0.001† |
65.2 ± 8.3 |
72.2 ± 8.8 |
0.002† |
| D10cc (Gy3) |
(μ ± σ) |
|
59.5 ± 6.4 |
63.4 ± 6.0 |
0.011† |
60.1 ± 6.7 |
62.7 ± 5.8 |
0.107† |
| D15cc (Gy3) |
(μ ± σ) |
|
56.3 ± 5.8 |
60.2 ± 5.0 |
0.004† |
56.8 ± 5.8 |
59.9 ± 5.3 |
0.034† |
| D20cc (Gy3) | (μ ± σ) | 55.4 ± 5.8 | 59.1 ± 4.8 | 0.006† | 55.9 ± 5.9 | 58.8 ± 4.9 | 0.040† | |
Abbreviations: DRP = doses to the reference points for the rectum; D0.1cc, D1cc, D2cc, D5cc, D10cc, D15cc, and D20cc = minimal doses received by the highest irradiated 0.1, 1, 2, 5, 10, 15, and 20 cc volumes of the rectosigmoid colon, respectively.; μ = mean; σ = standard deviation.
*Fisher’s exact test.
† Student’s t-test.