Figure 1. Effect of IUGR and neonatal exendin-4 treatment on neonatal growth.

Neonatal exendin-4 treatment reduced weight of twin IUGR lambs from 8 days of age (A), and abolished the negative relationship between birth weight and neonatal fractional growth rate (B). CON (white circle) and IUGR+Veh (black circle) lambs were treated once daily with vehicle (0.5% methanol in saline s.c.) and IUGR+Ex-4 (gray square) lambs were treated once daily with exendin-4 (1 nmol.kg⁻¹ s.c.). Data in Figure 1A are means ± SEM, and data in Figure 1B are individual animal outcomes. * different from CON (P<0.05), ? different from IUGR+Veh (P<0.05).