Table 2.
Insulin resistance and MetS components according to level of adiponectin, in eutrophic and obese children and adolescents
|
Adiponectin tertile(values) |
||||||
|---|---|---|---|---|---|---|
|
Eutrophic subjects(n = 196) |
Obese subjects(n = 190) |
|||||
| 3 | 2 | 1 | 3 | 2 | 1 | |
| Outcome variables |
(17.6-38.8) |
(12.6-17.5) |
(3.9-12.5) |
(13.4-27.5) |
(9.6-13.3) |
(1.4-9.5) |
| Insulin resistance |
|
|
|
|
|
|
| Fasting insulin (μm/mL) |
|
|
|
|
|
|
| Coefficient |
Referent |
0.9 |
1.1 |
Referent |
3.3 |
3.4 |
| 95% CI |
- |
−0.1; 1.9 |
0.1; 2.1 |
- |
−0.1; 6.5 |
0.2; 6.7 |
| P |
- |
0.083 |
0.032 |
- |
0.053 |
0.039 |
| HOMA-IR |
|
|
|
|
|
|
| Coefficient |
Referent |
0.2 |
0.3 |
Referent |
0.6 |
0.8 |
| 95% CI |
- |
−0.1; 0.4 |
0.1; 0.5 |
- |
−0.2; 1.3 |
0.1; 1.6 |
| P |
- |
0.123 |
0.035 |
- |
0.126 |
0.022 |
| Components of MetS |
|
|
|
|
|
|
| WC (cm) |
|
|
|
|
|
|
| Coefficient |
Referent |
0.9 |
3.1 |
Referent |
4.9 |
5.9 |
| 95% CI |
- |
−0.6; 2.4 |
1.6; 4.6 |
- |
2.1; 7.7 |
3.1; 8.7 |
| P |
- |
0.229 |
<0.001 |
- |
0.001 |
<0.001 |
| Blood pressure (mmHg) |
|
|
|
|
|
|
| SBP |
|
|
|
|
|
|
| Coefficient |
Referent |
0.8 |
1.9 |
Referent |
3.8 |
4.5 |
| 95% CI |
- |
−1.8; 3.5 |
−0.8; 4.5 |
- |
0.9; 6.7 |
1.6; 7.3 |
| P |
- |
0.538 |
0.168 |
- |
0.010 |
0.002 |
| DBP |
|
|
|
|
|
|
| Coefficient |
Referent |
1.6 |
2.5 |
Referent |
1.7 |
0.9 |
| 95% CI |
- |
−0.9;4.0 |
0.1; 5.0 |
- |
−1.0; 4.3 |
−1.8; 3.5 |
| P |
- |
0.213 |
0.043 |
- |
0.585 |
0.738 |
| Glucose (mg/dL) |
|
|
|
|
|
|
| Coefficient |
Referent |
0.1 |
0.5 |
Referent |
−0.4 |
3.9 |
| 95% CI |
- |
−3.6; 3.9 |
−3.2; 4.3 |
- |
−3.9; 3.1 |
−0.4; 7.4 |
| P |
- |
0.962 |
0.789 |
- |
0.140 |
0.029 |
| TGs (mg/dL) |
|
|
|
|
|
|
| Coefficient |
Referent |
−2.3 |
4.8 |
Referent |
14.4 |
27.3 |
| 95% CI |
- |
−13.5; 8.9 |
−6.2; 15.9 |
- |
−8.0; 36.8 |
4.9; 49.6 |
| P |
- |
0.931 |
0.391 |
- |
0.206 |
0.017 |
| HDL-C (mg/dL) |
|
|
|
|
|
|
| Coefficient |
Referent |
2.2 |
−0.3 |
Referent |
−1.3 |
−4.1 |
| 95% CI |
- |
−2.4; 6.8 |
−5.2; 4.5 |
- |
−5.3; 2.6 |
−8.1; 0.1 |
| P | - | 0.351 | 0.894 | - | 0.511 | 0.048 |
Values obtained through linear regression and adjusted for gender and body mass index percentile.
Regression coefficients are change in outcome variables per tertile change in adiponectin concentration.
MetS, metabolic syndrome; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; TGs, triglycerides; HDL-C, high-density lipoprotein cholesterol.