Fig. 1.

Hyperleptinemia induces extensive lipid depletion in adipose tissue. (A) Semithin section of normal epididymal fat pad tissue from control rats 14 days after infusion with β-galactosidase adenovirus. (B) Epididymal fat cells 14 days after infusion with leptin adenovirus. The cells are fat-depleted with a few residual lipid droplets and a highly indented surface. (C) Low magnification electron microscopic view showing a highly convoluted surface of postadipocytes embedded within an exceedingly thick layer of apparently amorphous material, which separates individual cells from the collagen-fibril-rich interstitial matrix.