Table 1. Relative changes in transcription factor mRNA content.
| Transcription factor
|
Days of hyperleptinemia
|
|||
|---|---|---|---|---|
| 0 (n = 4) | 7 (n = 4) | 10 (n = 3) | 14 (n = 3) | |
| PPARα | 1 ± 0.11 | 0.70 ± 0.16 | 1.02 ± 0.06 | 1.18 ± 0.08 |
| PPARγ | 1 ± 0.09 | 0.65 ± 0.09 | 0.60 ± 0.06 | 0.87 ± 0.06 |
| PPARδ | 1 ± 0.14 | 1.46 ± 0.31 | 0.86 ± 0.08 | 1.33 ± 0.11 |
| LXRα | 1 ± 0.20 | 2.36 ± 0.77* | 1.65 ± 0.09* | 2.08 ± 0.18* |
| SREBP-1c | 1 ± 0.09 | 0.45 ± 0.09* | 0.91 ± 0.06 | 1.39 ± 0.26 |
| ChREBP | 1 ± 0.31 | 0.25 ± 0.03* | 0.26 ± 0.11* | 0.58 ± 0.14* |
| FOXO1 | 1 ± 0.10 | 0.66 ± 0.13* | 0.17 ± 0.06* | 0.21 ± 0.07* |
| FOXC2 | 1 ± 0.18 | 2.47 ± 0.95* | 1.95 ± 0.09* | 4.84 ± 0.20* |
| C/EBPα | 1 ± 0.15 | 1.34 ± 0.35 | 0.81 ± 0.18 | 1.65 ± 0.22* |
*
, P < 0.05. LXR, liver X receptor; SREBP, sterol regulatory element-binding protein; ChREBP, carbohydrate-responsive element-binding protein; FOXO1, Forkhead transcription factor FKHR; FOXC2, another Forkhead transcription factor; C/EBP, CCAAT/enhancer-binding protein.