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. 2013 Jan 1;12(1):43–50. doi: 10.4161/cc.23108

Table 1. Mosaic RASopathies.

Mosaic RASopathy Gene Reported mosaic mutations References
Keratinocytic epidermal nevus
HRAS
KRAS
NRAS
(FGFR3)
G12C, G12V, G13R, Q61L
G12D
G12D, P34L, Q61R
R248C, S249C, G372C
8
8
8
8 , 14 , 45
Keratinocytic epidermal nevus syndrome
HRAS
KRAS
(FGFR3)
G12S
G12D
R248C, S249C
19
18
20 - 23
Sebaceous nevus
HRAS
KRAS
A11S, G12C, G12D, G12S, G13R
G12D, G12V
25
25
Schimmelpenning syndrome
HRAS
KRAS
G13R
G12D
25
25
Mosaic Costello syndrome
HRAS
G12S
32 , 33
Segmental neurofibromatosis type I NF1 Various point mutations, deletions, insertions 38 , 39