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Strategy to deliver the HPV16 genome to cells by using an Ad and Cre/LoxP system. Homologous recombination catalyzed by Cre recombinase should result in cells that contain a circular HPV16 genome and express eGFP. LoxP sites (P) flank the SphI site at nucleotide 7,465 in the HPV16 LCR. PCR primers designed to detect recombined HPV16 are indicated by blue arrows, and nonrecombination sensitive primers are shown as black arrows.
