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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Cancer Discov. 2012 Dec 7;3(2):224–237. doi: 10.1158/2159-8290.CD-12-0349

Figure 5.

Figure 5

HER2 mutants V777L, G309A, D769H formed tumors more rapidly than HER2 WT. A, 0.5×106 cells of NIH3T3 expressing either HER2 WT or mutant were injected in the flanks of nude mice. N=5 mice for each construct. Tumor size was measured every 2-3 days. A linear mixed effects model was fit to the logarithm of tumor volumes to statistically test whether HER2 mutants grew faster than HER2 WT. * = p<0.01. B, Photographs were taken on day 11. C, NIH3T3 cells expressing HER2 WT, G309A, or del.755-759 were injected into nude mice as in a. N=3 mice for G309A and WT and N=4 mice for del.755-759. * = p<0.01. D, Photographs taken on day 12.