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Inhibition of Cell Growth by Neratinib and Lapatinib. Cells were incubated with drugs for 6 days and cell viability and number was measured using Alamar Blue.
| IC50 (nM) | ||
|---|---|---|
| Neratinib | Lapatinib | |
| MCF10A - HER2 WT | <2 | 400 ± 60 |
| G309A | <2 | 470 ± 50 |
| V777L | <2 | 1,040 ± 570 |
| D769H | <2 | 980 ± 950 |
| V842I | <2 | 650 ± 210 |
| Del755-759 | 2.1 ± 0.2 | 660 ± 90 |
| L755S | 15 ± 6 | > 10,000 |
|
| ||
| BT474 cells | <2 | 31 ± 2 |
| MCF7 cells | > 3,000 | > 10,000 |
