Fig. 4.
Effect of DNA-PK on rAAV persistence in liver. (A) Equal generation of SCID and B6 liver after partial hepatectomy (PH). Each bar represents the mean of fresh liver weight at 8 weeks after PH (SCID, n = 6; B6, n = 5; P < 0.01). (B) Average of total copies of the vector genomes before and after partial hepatectomy (SCID, n = 6; B6, n = 5). Animals receiving 3 × 109 i.u. of rAAV2-CB-AT vector were subjected to partial hepatectomy (PH) at 16 weeks after injection. These animals were killed at 8 weeks after PH. Total rAAV DNA in all liver samples were detected by real-time PCR.