Figure 1.
Kaplan-Meier analysis of time to exacerbation in symptomatic patients with moderate asthma at baseline. The survival curves are shown separated by categories of P2X7 pore function defined by the receiver-operator curve generated threshold. The solid and the dashed lines represent the normal and low pore groups, respectively. Dots along these lines are the times of patient censure caused by completing participation without an exacerbation, including both the 16 weeks of the study medication and the run-out period; the variable time of completion is caused by variability in the length of the run-out. Six of 61 and 2 of 27 subjects in the normal and low pore groups dropped out of the study before completion of the treatment period (P = 0.7). The comparison of event rates was performed with correction for multiple events in a repeated measures proportional hazards regression model.