TABLE 3.

CHANGE IN ASTHMA CONTROL VARIABLES DURING ICS ADJUSTMENT IN PATIENTS WITH MILD ASTHMA STRATIFIED BY PORE FUNCTION

Change in Endpoints during ICS Adjustment	Low Pore (n = 40)	Normal Pore (n = 70)	Low to Normal
Juniper Asthma Control Questionnaire Average	0.10 (−0.14 to 0.35); 0.41	−0.07 (−0.26, 0.11); 0.44	0.18 (−0.13 to 0.48); 0.26
Daily Symptom Diary Scores	0.07 (0.05 to 0.09); <0.001	0.00 (−0.01 to 0.02); 0.97	0.07 (0.05 to 0.10); <0.001
Rescue albuterol use (puffs/day)	0.26 (0.13 to 0.39); <0.001	0.09 (0.01 to 0.18); 0.03	0.17 (0.01 to 0.32); 0.03
FEV1-albuterol reversal (4 puffs, %)	2.62 (0.75 to 4.50); 0.007	0.10 (−1.28 to 1.48); 0.89	2.52 (0.19 to 4.85); 0.03
Natural log(FeNO, ppb)	0.40 (0.10 to 0.70); 0.008	0.51 (0.29 to 0.73); <0.001	−0.11 (−0.48 to 0.26); 0.57
Log2(PC20, mg/ml)	−0.61 (−1.24 to 0.01); 0.05	−0.39 (−0.85 to 0.07); 0.10	−0.23 (−1.00 to 0.55); 0.56

Definition of abbreviations: Fe_NO = fraction of exhaled nitric oxide; ICS = inhaled corticosteroids; PC₂₀ = provocative concentration of methacholine.

All data are reported as estimate (95% confidence interval); P value. Data reflect the change in each endpoint from randomization to the end of the treatment period, with the last column representing the differences between the low and normal pore groups. The P values and 95% confidence intervals are reported from repeated measures analysis of covariance models.