TABLE 1.
CHARACTERISTICS OF VOLUNTEERS AND ALLERGENS USED FOR ASTHMA PROVOCATIONS (EACH SUBJECT UNDERWENT INHALED AND ENDOBRONCHIAL CHALLENGE USING THE SAME ALLERGEN)
| GSTM1+ | GSTM1− | |
| Male/female | 5/14 | 7/11 |
| Age | 29.8 ± 7.5 (20–43) | 28 ± 6.1 (20–42) |
| Race | ||
| Northern European ancestry | 15 | 18 |
| African American ancestry | 4 | 0 |
| Family history of atopy | 19 | 18 |
| Baseline spirometry | ||
| FVC, L | 4.1 ± 0.4 (3.38–4.7) | 4.9 ± 1.0 (3.5–6.5) |
| FVC, % predicted | 98.7 ± 9.9 (81–120) | 111.9 ± 17.9 (90–121) |
| FEV1, L | 3.15 ± 0.52 (2.6–3.9) | 3.65 ± 0.64 (2.84–4.7) |
| FEV1, % predicted | 84.6 ± 12.3 (65–111) | 94.9 ± 12.5 (77–122) |
| Treatment (regular or as needed) | ||
| Albuterol inhaler | 19 | 18 |
| Long-acting bronchodilator | 2 | 2 |
| Inhaled corticosteroids | 3 | 2 |
| Nasal corticosteroids | 2 | 1 |
| Montelukast | 1 | 4 |
| Antihistamines | 6 | 9 |
| Allergen used for challenge | ||
| Dust mite | 6 | 4 |
| Cat | 7 | 10 |
| Ragweed | 2 | 1 |
| Bermuda grass | 1 | 1 |
| Bluegrass | 1 | 1 |
| Rye grass | 1 | 1 |
| Timothy grass | 1 | 0 |
Data are presented as count or mean ± SD (range).