Table 2.

Bone mineral density measures in boys (left) and girls (right) with major depressive disorders (MDD) and healthy controls

	BOYS						GIRLS
	MDD (n=16)	Controls (n=16)	p	p*	p**	p***	MDD (n=17)	Controls (n=16)	p	p*	p**	p***
Lumbar spine BMD (g/cm2)	0.95 ± 0.18	0.96 ± 0.17	0.86	0.11	0.14	0.18	0.95 ± 0.12	0.92 ± 0.15	0.47	0.36	0.67	0.46
Lumbar spine BMD Z-score	− 0.26 ± 1.20	0.07 ± 1.06	0.41	0.025	0.035	0.024	− 0.51 ± 1.31	− 0.59 ± 1.02	0.85	0.17	0.27	0.32
Lumbar spine BMAD (g/cm2)	0.13 ± 0.02	0.14 ± 0.02	0.49	0.056	0.079	0.11	0.14 ± 0.02	0.14 ± 0.02	0.63	0.33	0.51	0.38
Hip BMD (g/cm2)	0.99 ± 0.17	1.04 ± 0.18	0.49	0.005	0.005	0.007	0.92 ± 0.10	0.90± 0.12	0.56	0.33	0.54	0.49
Hip BMD Z-score	− 0.29 ± 1.27	0.19 ± 1.28	0.30	0.004	0.005	0.006	− 0.24 ± 0.93	− 0.32 ± 0.99	0.80	0.31	0.48	0.55
Femoral Neck BMD (g/cm2)	0.92 ± 0.17	0.94 ± 0.17	0.64	0.024	0.015	0.020	0.84 ± 0.12	0.83 ± 0.12	0.77	0.23	0.37	0.36
Femoral Neck BMD Z-score	− 0.15 ± 1.26	0.15 ± 1.23	0.49	0.006	0.007	0.010	− 0.47 ± 1.06	− 0.41 ± 0.93	0.86	0.19	0.26	0.32

Mean ± SD

^*p-value after controlling for BMI;

^**p-value after controlling for BMI and lean mass;

^***p-value after controlling for BMI, lean mass and bone age;

p-values for the MDD x gender interaction term were non-significant for all bone density parameters

BMD: bone mineral density; BMAD: bone mineral apparent density