Table 3. Biological process categories overrepresented by incipient correlations (IADGs).
| Up-regulated (Total: 379/6,265; 6%) | ease | N/M/B | Down-regulated (Total: 154/6,265; 3%) | ease | N/M/B |
|---|---|---|---|---|---|
| Regulation of transcription, DNA... (64/781; 8%) | 0.008 | 30/49/21 | Protein folding (13/86; 15%) | 0.000 | 71/21/7 |
| Histogenesis and organogenesis (9/57; 16%) | 0.020 | 33/44/22 | Axon cargo transport (3/5; 60%) | 0.006 | 67/33/0 |
| Chromatin assembly/disassembly (8/52; 15%) | 0.035 | 22/78/0 | Synaptic transmission (10/143; 7%) | 0.008 | 33/67/11 |
| Cell proliferation (52/666; 8%) | 0.041 | 30/46/23 | Protein metabolism (46/1,415; 3%) | 0.028 | 64/28/9 |
| Cell adhesion (26/314; 8%) | 0.092 | 36/46/18 | Microtubule-based movement (4/33; 12%) | 0.046 | 50/50/0 |
| Development (61/850; 7%) | 0.103 | 38/43/19 | Electron transport (10/200; 5%) | 0.055 | 45/36/18 |
| Protein amino acid phosphorylation (25/310; 8%) | 0.122 | 38/46/15 | Cytokinesis (5/61; 8%) | 0.061 | 60/20/20 |
| Cell motility (16/182; 9%) | 0.134 | 35/41/24 | Intracellular transport (15/369; 4%) | 0.066 | 58/37/5 |
| Lipid metabolism (23/288; 8%) | 0.148 | 48/39/13 | GPCR signaling pathway (11/264; 4%) | 0.111 | 33/53/13 |
| Apoptosis (20/244; 8%) | 0.150 | 24/62/14 | Cell surface signal transduction (17/492; 4%) | 0.145 | 43/48/10 |
Biological process categories significantly overrepresented by IADGs (P ≤ 0.15; ease score) and a few other selected categories are shown. Numerous other similar significant categories are not included to reduce redundancy. Significant functional categories are those with a higher ratio of identified genes to all genes tested on the array for associations with that category, relative to the ratio of total identified genes in the study to all genes tested on the array for associations with all categories. The association numbers approximate but are not exactly equal to gene numbers in a category. After each category description (in parentheses) is the ratio of associations for that category and the percentage represented by that ratio. The analogous ratios for total identified up-regulated and down-regulated genes are shown in the headings (Total). ease, modified Fisher's exact test P value; N/M/B, percentage of genes included in category because they were significant by NFT correlation (N), MMSE correlation (M), or both (B). (The complete list of IADGs is given alphabetically in Table 6).