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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Neurobiol Aging. 2012 Dec 20;34(5):1416–1425. doi: 10.1016/j.neurobiolaging.2012.11.014

Fig. 1.

Fig. 1

Aggregation profile and cytotoxicity of pGlu-modified ABri/ADan peptides. Compared to ABri peptides, pGlu-ABri peptides showed a much more rapid formation of intermediate oligomeric assemblies and strongly enhanced fibril formation in a Thio-T assay (A). Application of 5 µM non-modified ABri or ADan peptides did not influence cell viability in SH-SY5Y cells as measured by LDH release, however, incubation with both pGlu-modified ABri as well as ADan peptides resulted in a significantly increased toxicity (B). Dotted lines in A indicate s.e.m.