Table 3. Functional connectivity correlates of childhood maltreatment during angry face vs. shape processing.
| Seed | Mask | Hemisphere | Anatomical Area | Volume(μl) | X | Y | Z | Voxelwise Stats: Mean (SD) | Extracted rho (sig) † | ΔR2(sig.) † | Group Diff.† | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T | p | T, p | ||||||||||
| RAmyg | -- | -- | No significant associations | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| LPIns | ROI | R | Amygdala (−) | 320 | 23 | −3 | −12 | −2.58(0.41) | 0.020(0.017) | −0.503(0.003) | 0.178(0.016) | −2.274, 0.030 |
| LAmyg | ROI | L | Insula (m)(−) | 960 | −41 | 5 | 3 | −2.75(0.47) | 0.016(0.015) | −0.499(0.003) | 0.193(0.009) | −2.045, 0.049 |
| LMFG | WB | L | Culmen/Declive/Fusiform Gyrus/Parahippocampal Gyrus |
7552 | −11- | −47 | −10 | 2.60(0.51) | 0.022(0.015) | 0.599(<0.001) | 0.335(<0.001) | 3.943, <0.001 |
| LMFG | WB | R | Culmen/Declive/Lingual Gyrus/Parahippocampal Gyrus |
4352 | 18 | −62 | −9 | 2.65(0.44) | 0.019(.013) | 0.558(0.001) | 0.258(0.001) | 3.870, 0.001 |
| RMFG | ROI | R | Anterior Cingulate (pg) | 960 | 5 | 39 | −4 | 2.89(0.83) | 0.021(0.017) | 0.500(0.003) | 0.225(0.007) | 2.239, 0.032 |
Cluster coordinates are for cluster center of mass as defined by Talairach stereotactic space; Negative (−) signs following anatomical area indicate a negative relationship; Extracted rho is the spearman's correlation of extracted Fisher Z-transformed correlation coefficient and Childhood Trauma Questionnaire total score; ΔR2 represents the change in full model R2 and significance from inclusion of CTQ total score in a post-hoc regression of extracted Fisher Z-transformed correlation coefficients against other model factors; Group Diff. column represents the post-hoc t-test (High CM vs. Low CM) of extracted Fisher Z-transformed correlation coefficients based upon a median split of IPV-PTSD sample into low and high CM-exposure groups; Descriptors for anatomical areas do not reflect stereotactic distinctions, but are estimates based upon the relative location of activation on the group map; Seed regions and descriptors were derived from task-dependent activation for the contrast of interest; Statistics with a † indicate a circular estimate and therefore may be inflated estimates of the true population parameter; L=left; LAmyg=left amygdala; LMFG=left middle frontal gyrus; LPIns=left posterior insula; m=middle; pg=perigenual; R=right; ROI=region of interest; RAmyg=right amygdala; RMFG=right middle frontal gyrus; WB=whole-brain.