Table 1.
Total number of mice used in each condition.
| Treatment | Neurogenesis Measured | Water Maze Training Initiated | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| 5h | 1 week | 1 month | 1 week | Excluded | 1 month | Excluded | |
| Does LPS impact neurogenesis and water maze performance?
| |||||||
| Saline | 3 | 7 | 5 | 12† | (4)‡ | 12 | (3)‡ |
| 5.0mg/kg LPS | 3 | 5 | 5 | 12† | (4)‡ | 12 | (2)‡ |
|
| |||||||
| Can NSAIDs protect neurogenesis and behavior from LPS?
| |||||||
| Saline | |||||||
| Milk Vehicle | - | - | 4 | - | - | 13 | (4) ‡ |
| Rosiglitazone | - | - | 4 | - | - | 9 | - |
| Indomethacin | - | - | 4 | - | - | 6 | - |
| Celecoxib | - | - | 4 | - | - | 12 | (5) ‡ |
|
| |||||||
| 5.0mg/kg LPS | |||||||
| Milk Vehicle | - | - | 4 | - | - | 12 | (2) ‡ |
| Rosiglitazone | - | - | 4 | - | - | 6 | (1) ‡ |
| Indomethacin | - | - | 4 | - | - | 16 | - |
| Celecoxib | - | - | 4 | - | - | 13 | (5) ‡ |
|
| |||||||
| Can OTC NSAIDs protect neurogenesis from LPS?
| |||||||
| Saline | |||||||
| Milk Vehicle | - | - | 4 | - | - | - | - |
| 5.0mg/kg LPS | |||||||
| Milk Vehicle | - | - | 4 | - | - | - | - |
| SC-560 | - | - | 5 | - | - | - | - |
| Ibuprofen | - | - | 5 | - | - | - | - |
| Acetaminophen | - | - | 5 | - | - | - | - |
|
| |||||||
| Total Mice | 6 | 12 | 73 | 24 | (8) ‡ | 111 | (22) ‡ |
†
Mice were tested in locomotor activity chambers before water maze training.
‡
Mice were excluded from statistical analyses because they either failed training criterion or exhibited immobility or thigmotaxia for > 80% of the duration of the probe trial.