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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Dev Biol. 2012 Dec 19;375(1):92–104. doi: 10.1016/j.ydbio.2012.11.033

Figure 7.

Figure 7

GRN for establishment and maintenance of the aboral NSM regulatory state. A) Prior to NSM subdivision Delta signaling emanating from the skeletogenic mesoderm (SM) activates gcm. Both Delta and Gcm activate gataE transcription as part of a coherent feed forward loop. Delta signaling also serves to clear endoderm genes by interference with TCF/β-catenin, the main driver of endoderm genes. Presence of HesC prevents delta expression. B) Following separation of NSM segments, the aboral NSM regulatory state is locked down through positive feedback between gataE, six1/2–eya and gcm. This subcircuit is thus independent of the initial Delta input. Repression of delta is relieved after clearance of HesC.