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. Author manuscript; available in PMC: 2014 Feb 11.
Published in final edited form as: ACS Comb Sci. 2013 Jan 7;15(2):120–129. doi: 10.1021/co300136j

Table 1.

Cyclization Efficiency of Small- to Medium-Sized Peptides

Library No.
(sequence)		 Theoretical
diversity		 Fast Cyclization Sequences Slow Cyclization Sequences
No of
beads
screened		 No. of
colorless
beads at
2 or 5
min (%)		 No. of
beads
sequenced
(No. of full
sequences)		 No of
beads
with
dimer
formation		 No. of
beads
screened		 No. of
colored
beads at 90
min (%)		 No. of full
sequences		 No. of
beads with
dimer
formation
I X3E 8.0 × 103 30,000 75 20 (11) 6 (54%) 30,000 25 (0.083) 15 2 (13%)
II X4E 1.6 × 105 60,000 70 20 (11) 8 (73%) 60,000 13 (0.02) 7 1 (14%)
III X5E 3.2 × 106 210,000 65 101 (46) 2 (4.3%) 210,000 75 (0.036) 50 1 (2.0%)
IV X6E 6.4 × 107 210,000 65 89 (61) 0 (0%) 210,000 51 (0.024%) 34 0 (0%)
V X7E 1.3 × 109 420,000 60 126 (109) 1 (0.9%) 420,000 166 (0.04%) 157 0 (0%)