Table 2.
entry | peptide | Cyclic Monomer (%) |
Linear (%) |
Cyclic Dimer (%) |
---|---|---|---|---|
1 | PNPEb | 99 | 0 | 1 |
2 | NFFPEb | 3 | 0 | 97 |
3 | GGDNHEb | 97 | 0 | 3 |
4 | IHLENFEb | 100 | 0 | 0 |
5 | HEMIHYPEb | 100 | 0 | 0 |
6 | TTKEc | 39 | 61 | 0 |
7 | TKYAEc | 100 | 0 | 0 |
8 | TKTRREc | 100 | 0 | 0 |
9 | TKYRREc | 72 | 28 | 0 |
10 | SKKFRHEc | 100 | 0 | 0 |
11 | KVTYRREc | 52 | 31 | 17 |
12 | TKKVSYKEc | 100 | 0 | 0 |
13 | IKYKTNKEc | 45 | 55 | 0 |
Entry 1–5 are fast cyclizing peptides selected from the libraries, whereas entry 6–13 are poorly cyclizing peptides. All peptides contained the C-terminal sequence BBNRM.
Data from MS analysis
Data from HPLC and MS analysis