Table 2.
Solid-phase N-to-C cyclization of selected peptidesa
| entry | peptide | Cyclic Monomer (%) |
Linear (%) |
Cyclic Dimer (%) |
|---|---|---|---|---|
| 1 | PNPEb | 99 | 0 | 1 |
| 2 | NFFPEb | 3 | 0 | 97 |
| 3 | GGDNHEb | 97 | 0 | 3 |
| 4 | IHLENFEb | 100 | 0 | 0 |
| 5 | HEMIHYPEb | 100 | 0 | 0 |
| 6 | TTKEc | 39 | 61 | 0 |
| 7 | TKYAEc | 100 | 0 | 0 |
| 8 | TKTRREc | 100 | 0 | 0 |
| 9 | TKYRREc | 72 | 28 | 0 |
| 10 | SKKFRHEc | 100 | 0 | 0 |
| 11 | KVTYRREc | 52 | 31 | 17 |
| 12 | TKKVSYKEc | 100 | 0 | 0 |
| 13 | IKYKTNKEc | 45 | 55 | 0 |
a
Entry 1–5 are fast cyclizing peptides selected from the libraries, whereas entry 6–13 are poorly cyclizing peptides. All peptides contained the C-terminal sequence BBNRM.
b
Data from MS analysis
c
Data from HPLC and MS analysis