Table 3.
entry | peptide | Monocyclic | Linear | Dimer | Trimer |
---|---|---|---|---|---|
1 | PNPEc | +b | +++ | ++ | + |
2 | NFFPEc | + | − | ++ | + |
3 | GGDNHEc | +++ | − | − | − |
4 | IHLENFEc | +++ | +++ | +++ | − |
5 | HEMIHYPEd | +++ | − | + | − |
6 | TTKEc | + | − | − | − |
7 | TKYAEc | + | − | ++ | + |
8 | TKTRREd | +++ | +++ | ++ | − |
9 | SKKFRHEc | +++ | + | + | − |
10 | TKKVSYKEc | +++ | +++ | − | − |
Entry 1–5, fast cyclizing peptides from library screening; entry 6–10, poorly cyclizing peptides.
Semiquantitation of the amount of each species observed, with “+” representing small amounts, “+++” indicating large amounts, whereas “−“ indicating the absence of a given species.
Data from MS analysis
Data from HPLC and MS analysis