Table 3.
Solution-phase N-to-C cyclization of selected peptidesa.
| entry | peptide | Monocyclic | Linear | Dimer | Trimer |
|---|---|---|---|---|---|
| 1 | PNPEc | +b | +++ | ++ | + |
| 2 | NFFPEc | + | − | ++ | + |
| 3 | GGDNHEc | +++ | − | − | − |
| 4 | IHLENFEc | +++ | +++ | +++ | − |
| 5 | HEMIHYPEd | +++ | − | + | − |
| 6 | TTKEc | + | − | − | − |
| 7 | TKYAEc | + | − | ++ | + |
| 8 | TKTRREd | +++ | +++ | ++ | − |
| 9 | SKKFRHEc | +++ | + | + | − |
| 10 | TKKVSYKEc | +++ | +++ | − | − |
a
Entry 1–5, fast cyclizing peptides from library screening; entry 6–10, poorly cyclizing peptides.
b
Semiquantitation of the amount of each species observed, with “+” representing small amounts, “+++” indicating large amounts, whereas “−“ indicating the absence of a given species.
c
Data from MS analysis
d
Data from HPLC and MS analysis