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. 2004 Feb 9;101(7):2191–2196. doi: 10.1073/pnas.0308652100

Fig. 4.

Fig. 4.

Inhibition of CDK5 increases NR1 phosphorylation levels and involves dopamine D1 receptors. (A) Effect of 10 μM roscovitine (Rosc), 10 μM butyrolactone I (But), and 10 μM SCH23390 on Ser897-NR1 phosphorylation. ***, P < 0.001 compared with control slices without SCH23390; ##, P < 0.01 compared with roscovitine or butyrolactone I in the absence of SCH23390. (B) Effect of 10 μM roscovitine and 10 μM d-amphetamine (Amph) on phosphorylation of Ser897-NR1 in dopamine D1 receptor knockout (D1KO) mice. ***, P < 0.001 compared with slices from wild-type (WT) mice; ##, P < 0.01; ###, P < 0.001 compared with roscovitine or amphetamine in slices from wild-type animals. (C) Effect of 10 μM roscovitine and 10 μM d-amphetamine on phosphorylation of Ser897-NR1 in intact and dopamine-depleted striatal slices from unilaterally 6-OHDA-lesioned rats. ***, P < 0.001 compared with control intact slices; ###, P < 0.001 compared with roscovitine or amphetamine in intact slices. All statistical analyses were made by using one-way ANOVA followed by Newman-Keul's test for pairwise comparisons.