Table 1.
Sonoclot analysis of whole blood platelet function on clot retraction by r-Cam-dis and r-mojastin-1.
| Sample | Platelet functiona Mean ± SD (n=3) | P value |
|---|---|---|
| Controlb | 2.63 ± 0.31 | - |
| r-Cam-dis (0.3 μg/mL) | 2.63 ± 0.38 | 1.00 |
| r-Cam-dis (1 μg/mL) | 0.23 ± 0.15 | 0.0003 |
| r-Cam-dis (6 μg/mL) | 0.17 ± 0.06 | 0.0002 |
| r-Mojastin-1 (29 μg/mL)c | 3.00 ± 0.44 | 0.30 |
| Cleaved Nus tag | 2.90 ± 0.89 | 0.65 |
Bold letter indicates the significant reduction of the platelet function by r-Cam-dis compared with the control at P < 0.05.
a
Platelet function is defined as the function of clot retraction. A platelet function greater than 1 represents normal clot retraction. A platelet function of less than 1 represents no clot retraction.
b
The control was citrated blood that was activated with glass beads contained in the cuvette and 0.3 M CaCl2.
c
r-Mojastin-1 at a final concentration of 29 μg/mL (4 μM) was used for comparison.